Speakers 2023

Speakers 2023

Christelle MONVILLE


Professeur des Universités - VP Recherche Evry

Christelle Monville obtained a PhD in Neurobiology in 2000. She is currently professor at Paris Saclay-Evry’s University and team leader at the Istem lab (France). The objectives of her group are (1) to develop pre-clinical studies required for the development of human pluripotent stem cells cellular therapy for the treatment of a number of monogenic retinal diseases and (2) disease modeling and drug discovery using patient-specific human induced Pluripotent Stem. Replacement of defective retinal pigment epithelium (RPE) by new RPE cells derived from human embryonic stem cells (hESC) provides a novel rational approach for treating forms of blindness that affect the RPE. We successfully developed a tissue-engineered product consisting of RPE cells derived from hESCs disposed on the human amniotic membrane. A clinical trial on patients suffering from Retinitis Pigmentosa (NCT03963154) is ongoing. The future will be to provide more complex tissue and upscale the production of retinal cells.

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